Roxborough is located in the Northwest section of Philadelphia. It’s bordered by: the Schuylkill River on the southwest, Manayunk, along the northeast by the Wissahickon Creek section of Fairmount Park, East Falls to the southeast, and Montgomery County to the northwest. The economic outlook is ever changing as gentrification continues throughout Roxborough, Manayunk, and East Falls. Tree-lined streets and front lawns provide a suburban feel. The area is very popular with young professionals due to its close proximity to various medical schools and universities. Philadelphia University and St. Joseph's University are nearby.

Due to the Wissahickon Creek and Fairmount Park, which protects much of its watershed, Roxborough and Manayunk are physically separated from the rest of the city. Much of lower Roxborough, consists of row homes dating from the 1800s to 1900s, providing historic, urban character. The section of Fairmount Park closest to Roxborough is known as Valley Green which stretches from Chestnut Hill and Mt. Airy to Center City Philadelphia. The park's numerous trails are used by cyclists, runners, walkers, dog owners and mountain bikers. Gorgas Park, is located on Ridge Avenue and offers a modern playground for the kids and colorful vistas across the city. Upper Roxborough’s development occurred circa 1950, and offers suburban character, single family homes, spacious front lawns, garages, and shopping centers.

If you’re looking for a game of golf with reasonable green fees be sure to check out Walnut Lane Golf Club, a public 18-hole course, located in Wissahickon Valley Park at 800 Walnut Lane. Designed by legendary architect, Alex Findlay, the tree-lined course with scenic hills and valleys, that opened in 1940, challenges golfers short game highlighted by several par 3’s. The club features “The First Tee” program for kids with year-round 8 week sessions group instruction scheduled on Saturdays. Pros are available for private adult instruction as well. 215-482-3370.

Since the 1950s, most of Philadelphia's major television and FM radio stations have located their transmission towers in Roxborough due to its hilly terrain and high elevation. Public television station WYBE calls Roxborough “home”.

Philadelphia public schools in Roxborough include: Roxborough High School, Cook Wissahickon, and Shawmont Elementary. William Levering School, founded in 1748, closed its doors in June of 2012; however the building is slated to be the new home of, AMY Northwest, a special admissions middle school (grades 6-8).

Reaching Roxborough is easy due to its multiple bus routes and bike lanes reaching the river and Center City Philadelphia; SEPTA's Manayunk/Norristown Regional Rail line; and Ivy Ridge station in Roxborough.